Autophagy-related Protein (atg) 8-family Interacting Motif in Atg3 Mediates the Atg3-atg8 Interaction and Is Crucial for the Cytoplasm-to-vacuole Targeting Pathway*
نویسندگان
چکیده
AUTOPHAGY-RELATED PROTEIN (ATG) 8-FAMILY INTERACTING MOTIF IN ATG3 MEDIATES THE ATG3-ATG8 INTERACTION AND IS CRUCIAL FOR THE CYTOPLASM-TO-VACUOLE TARGETING PATHWAY* Masaya Yamaguchi, Nobuo N. Noda, Hitoshi Nakatogawa§, Hiroyuki Kumeta, Yoshinori Ohsumi, and Fuyuhiko Inagaki Department of Structural Biology, Graduate school of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Integrated Research Institute, Tokyo Institute of Technology, Yokohama 226-8503, and ¶ PRESTO, Japan Science and Technology Agency, Saitama 332-0012, Japan Running head: Atg3-Atg8 interaction crucial for the Cvt pathway Address correspondence to: Fuyuhiko Inagaki, Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N-12, W-6, Kita-ku, Sapporo 060-0812, Japan, Tel. +81-11-706-9011; Fax. +81-11-706-9012; E-mail: [email protected]
منابع مشابه
Autophagy-related protein 8 (Atg8) family interacting motif in Atg3 mediates the Atg3-Atg8 interaction and is crucial for the cytoplasm-to-vacuole targeting pathway.
The autophagy-related protein 8 (Atg8) conjugation system is essential for the formation of double-membrane vesicles called autophagosomes during autophagy, a bulk degradation process conserved among most eukaryotes. It is also important in yeast for recognizing target vacuolar enzymes through the receptor protein Atg19 during the cytoplasm-to-vacuole targeting (Cvt) pathway, a selective type o...
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